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Impaired myofilament contraction drives right ventricular failure secondary to pressure overload: model simulations, experimental validation, and treatment predictions

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Pulmonary vascular collagen content, not cross-linking, contributes to right ventricular pulsatile afterload and overload in early pulmonary hypertension.

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Reduced haemodynamic coupling and exercise are associated with vascular stiffening in pulmonary arterial hypertension.

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Estrogen preserves pulsatile pulmonary arterial hemodynamics in pulmonary arterial hypertension.

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17?-estradiol mediates superior adaptation of right ventricular function to acute strenuous exercise in female rats with severe pulmonary hypertension.

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Limiting collagen turnover via collagenase-resistance attenuates right ventricular dysfunction and fibrosis in pulmonary arterial hypertension.