David Schreier, PhDUndergraduate Student
I have been a member of the VTB lab since Spring of 2009. I have worked on numerous projects during my time with the lab focusing on right ventricular contractility, pulmonary hemodynamics, a novel technique of assessing pulmonary vascular impedance, and the role of collagen during the progression of pulmonary hypertension.
Since 2015 I have been working on my thesis which is titled Pulmonary Hypertension Associated with Sickle Cell Disease. A F31 grant from the NIH funds me to work on this project as well as a R21 which funds the experiments.
Research Project Description for David Schreier:
- Investigate altered pulmonary hemodynamics (by in vivo impedance measurements) and their relationship to right heart dysfunction (by in vivo pressure-volume loop measurements) in pulmonary hypertension assocaited with sickle cell disease using small animal models of sickle cell anemia
- Investigate the role red blood cells and chronic anemia play during the progression of hypoxic pulmonary hypertension secondary to sickle cell disease in a small animal model
- Investigate how chronic anemia and other side effects of sickle cell disease affect pulmonary vascular compliance and right ventricular function during the progression of pulmonary hypertension.