In a recent episode, Dr. Zamaneh Kassiri interviews our lab members and collaborators (Dr. Oliver H. Wearing, Dr. Naomi C. Chesler, Dr. Mitchel J. Colebank, Dr. Timothy A. Hacker, Dr. John N. Lorenz, and Dr. Christopher R. West), about their Guidelines in Cardiovascular Research article on ventricular pressure-volume (PV) measurements in mice. They discuss why PV is the gold standard for assessing cardiac function and how it complements echocardiography. Tune in to learn more about this essential method for cardiovascular research! [DOI: 10.1152/ajpheart.00434.2024]